Biochemical markers may identify preterm infants with a patent ductus arteriosus at high risk of death or severe intraventricular haemorrhage
- 1Department of Neonatology, National Maternity Hospital, Dublin, Ireland
- 2Department of Paediatric Cardiology, Our Lady’s Children Hospital, Crumlin, Ireland
- 3Neonatal Services, Royal Women’s Hospital, Carlton, Victoria, Australia
- Afif El-Khuffash, National Maternity Hospital, Holles Street, Dublin 2, Ireland;
- Accepted 5 February 2008
- Published Online First 19 February 2008
Background: A patent ductus arteriosus (PDA) in preterm infants is associated with increased risk of intraventricular haemorrhage (IVH) and death. Cardiac troponin T (cTnT) and N-terminal-pro-B type natriuretic peptide (NTpBNP) are markers of cardiac function and can predict poor outcome in adults.
Aims: To determine whether echocardiography and cTnT/NTpBNP levels at 48 h predict death before discharge or severe IVH in preterm infants with a PDA.
Methods: Infants born <32 weeks' gestation or <1500 g underwent echocardiographic and cTnT/NTpBNP measurements at 12 and 48 h of life. Infants were divided according to their status at discharge: a closed PDA at 48 h, infants with a PDA at 48 h and IVH III/IV and/or death, and infants with a PDA at 48 h without IVH III/IV or death.
Results: Eighty infants with a median gestation of 28 weeks (IQR 26.1–29.5) and birth weight 1.06 kg (0.8–1.21) were included. At 48 h, infants with a PDA and IVH III/IV and/or death had significantly higher median cTnT/NTpBNP levels compared to infants with a PDA without IVH III/IV and/or death and those with spontaneous PDA closure (NTpBNP 9282, 5121 and 740 pmol/l, respectively, p = 0.008, and cTnT 0.66, 0.25 and 0.13 µg/l, respectively, p = 0.027). There were no differences in echocardiographic parameters of PDA size, left atrial to aortic ratio (LA:Ao), left and right ventricular outputs between the PDA groups.
Conclusions: NTpBNP and cTnT in conjunction with echocardiography may provide a basis for trials of targeted medical treatment in infants with a PDA.
Competing interests: None.
Funding: National Maternity Hospital Research Fund.
Ethics approval: The study was approved prior to commencement by the National Maternity Hospital’s Ethics Committee, Dublin, Ireland.
Patient consent: Informed parental consent was requested within the first 24 h of life.