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West syndrome in extremely preterm infants: its relation to postnatal events
  1. A Okumura1,
  2. M Suzuki2,
  3. T Kubota3,
  4. K Hisada1,
  5. H Kidokoro3,
  6. T Kato2,
  7. F Hayakawa2,
  8. T Shimizu1
  1. 1
    Department of Paediatrics, Juntendo University School of Medicine, Tokyo, Japan
  2. 2
    Department of Paediatrics, Okazaki City Hospital, Japan
  3. 3
    Department of Paediatrics, Anjo Kosei Hospital, Japan
  1. Dr A Okumura, Department of Paediatrics, Juntendo University School of Medicine, 2–1–1 Hongo, Bunkyo-ku, Tokyo, 113–8421 Japan; okumura{at}med.juntendo.ac.jp

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West syndrome (WS) is the epileptic encephalopathy caused by various brain disorders. Although severe periventricular leucomalacia in preterm infants is related to later development of WS,1 there have been no studies of WS in extremely preterm infants. We investigated the relation between postnatal events and later development of WS in extremely preterm infants.

Box 1 Definition of late-onset circulatory dysfunction

  • Hypotension with mean arterial pressure <80% of those before the episode, refractory to volume expanders or inotropic agents.

  • Electrolyte derangement, including hyponatraemia <130 mEq/l or hyperkalaemia >7 mEq/l, or both.

  • Oliguria <1 ml/kg/h lasting for 8 hours or longer.

  • An episode occurred in …

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