Cognitive assessment of children at age 2½ years after maternal fish oil supplementation in pregnancy: a randomised controlled trial
- 1School of Paediatrics and Child Health, University of Western Australia, Perth, Western Australia, Australia
- 2Telethon Institute for Child Health Research, Centre for Child Health Research, The University of Western Australia, Western Australia, Australia
- A/Professor S L Prescott, School of Paediatrics and Child Health, University of Western Australia, Princess Margaret Hospital, PO Box D184, Perth, WA 6840, Australia; susanp{at}ichr.uwa.edu.au
- Accepted 19 September 2006
- Published Online First 21 December 2006
Abstract
Objective: To assess the effects of antenatal omega 3 long-chain polyunsaturated fatty acid (n-3 LC PUFA) on cognitive development in a cohort of children whose mothers received high-dose fish oil in pregnancy.
Design: A double-blind randomised placebo-controlled trial.
Setting: Perth, Western Australia, Australia.
Patients: 98 pregnant women received the supplementation from 20 weeks’ gestation until delivery. Their infants (n = 72) were assessed at age 2½ years.
Interventions: Fish oil (2.2 g docosahexaenoic acid (DHA) and 1.1 g eicosapentaenoic acid (EPA)/day) or olive oil from 20 weeks’ gestation until delivery.
Outcome measures: Effects on infant growth and developmental quotients (Griffiths Mental Development Scales), receptive language (Peabody Picture Vocabulary Test) and behaviour (Child Behaviour Checklist).
Results: Children in the fish oil-supplemented group (n = 33) attained a significantly higher score for eye and hand coordination (mean ((SD) score 114 (10.2)) than those in the placebo group (n = 39, mean score 108 (SD 11.3); p = 0.021, adjusted p = 0.008). Eye and hand coordination scores correlated with n-3 PUFA levels in cord blood erythrocytes (EPA: r = 0.320, p = 0.007; DHA: r = 0.308, p = 0.009) and inversely correlated with n-6 PUFA (arachidonic acid 20:4n-6: r = −0.331, p = 0.005). Growth measurements in the two groups were similar at age 2½ years.
Conclusion: Maternal fish oil supplementation during pregnancy is safe for the fetus and infant, and may have potentially beneficial effects on the child’s eye and hand coordination. Further studies are needed to determine the significance of this finding.
Footnotes
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Funding: This study was funded by a grant from the Raine Medical Research Foundation of Western Australia and a grant from the National Health and Medical Research Foundation of Australia. Dr Janet Dunstan is supported by the Child Health Research Foundation of Western Australia.
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Competing interests: None.
