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The diagnosis of a haemodynamically significant patent ductus arteriosus (sPDA) in preterm infants is often difficult, with echocardiography remaining the gold standard.1 However, availability and cost pose some difficulties. B-type natriuretic peptide (BNP) may assist diagnosis, but cut-off levels vary widely in the literature. No data exist on the applicability of the byproduct N-terminal pro-B-type natriuretic peptide (NTpBNP), which is more stable and has a longer half life.2 We hypothesised that NTpBNP may be useful in the management of preterm infants with sPDA and aimed to investigate its usefulness as a marker of sPDA and treatment success.
The local ethics committee approved the study, and informed written parental consent was obtained from all parents prior …
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