Objective: To explore the differences in outcome of very preterm pregnancies between two geographically defined populations in Europe with similar socioeconomic characteristics and healthcare provision but different organisational arrangements for perinatal care.
Design: Prospective cohort study.
Setting: Nord Pas-de-Calais (NPC), France, and Trent, UK.
Participants: All pregnancy outcomes 22+0 to 32+6 weeks’ gestational age for resident mothers.
Outcome measures: Mortality patterns (antepartum death, intrapartum death, labour ward death and neonatal unit death) among very preterm babies were analysed by region. Multinomial logistic regression was used to model regional differences for a variety of pregnancy outcomes and to adjust for regional differences in the organisation of perinatal care.
Results: Delivery of very preterm infants was significantly higher in Trent compared with NPC (1.9% v 1.5% of all births, respectively (p<0.001)). Stillbirth rate was significantly higher in NPC than in Trent (23.0%, 95% CI 20.0% to 26.5% v 14.4%, 95% CI 12.3% to 16.6%, respectively (p<0.001)) and survival to discharge was higher in Trent than in NPC (74.6%, 95% CI 71.9% to 77.1% v 66.7%, 95% CI 63.3% to 69.9%, respectively (p<0.001)). Probability of intrapartum and labour ward death in NPC was more than five times higher than Trent (relative risk 5.3, 95% CI 2.2 to 13.1 (p<0.001)).
Conclusion: The high rate of very preterm deliveries and the larger proportion of these infants recorded as live born in Trent appear to be the cause of the excess neonatal mortality seen in the routine statistics. Information about very preterm babies (not usually included in routine statistics) is vital to avoid inappropriate interpretation of international perinatal and infant data. This study highlights the importance of including deaths before transfer to neonatal care and emphasises the need to include the outcome of all pregnancies in a population in any comparative analysis.
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The TNS was funded via a National Health Service regional levy for all health districts within the former Trent Health Region. This study was funded as part of an INSERM (the French National Institute of Health and Medical Research) research project based on existing multiple databases. ESD is funded by the Eastern Leicester Primary Care Trust.
The funders had no involvement in the collection, analysis and interpretation of the data, nor in the writing of the paper or decision to submit the paper for publication.
Competing Interests: None.
- Confidential Enquiry into Stillbirths and Deaths in Infancy
- Nord Pas-de-Calais
- Trent Neonatal Survey
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