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Customised birthweight standards accurately predict perinatal morbidity
  1. Francesc Figueras1,
  2. Josep Figueras2,
  3. Eva Meler1,
  4. Elisenda Eixarch1,
  5. Oriol Coll1,
  6. Eduard Gratacos1,
  7. Jason Gardosi3,
  8. Xavier Carbonell2
  1. 1Obstetrics Department, Hospital Clinic, Barcelona, Spain
  2. 2Neonatology Department, ICGON, IDIBAPS, Agrupació Sanitària Hospital Clínic—Hospital Sant Joan de Déu, Universitat de Barcelona, Spain
  3. 3West Midlands Perinatal Institute, Birmingham, UK
  1. Correspondence to:
    Francesc Figueras
    Perinatal Institute, Crystal Court, Aston Cross, Birmingham, B6 5RQ; Francesc.Figueras{at}perinatal.nhs.uk

Abstract

Objective: Fetal growth restriction is associated with adverse perinatal outcome but is often not recognised antenatally, and low birthweight centiles based on population norms are used as a proxy instead. This study compared the association between neonatal morbidity and fetal growth status at birth as determined by customised birthweight centiles and currently used centiles based on population standards.

Design: Retrospective cohort study.

Setting: Referral hospital, Barcelona, Spain.

Patients: A cohort of 13 661 non-malformed singleton deliveries.

Interventions: Both population-based and customised standards for birth weight were applied to the study cohort. Customised weight centiles were calculated by adjusting for maternal height, booking weight, parity, ethnic origin, gestational age at delivery and fetal sex.

Main outcome measures: Newborn morbidity and perinatal death.

Results: The association between smallness for gestational age (SGA) and perinatal morbidity was stronger when birthweight limits were customised, and resulted in an additional 4.1% (n = 565) neonates being classified as SGA. Compared with non-SGA neonates, this newly identified group had an increased risk of perinatal mortality (OR 3.2; 95% CI 1.6 to 6.2), neurological morbidity (OR 3.2; 95% CI 1.7 to 6.1) and non-neurological morbidity (OR 8; 95% CI 4.8 to 13.6).

Conclusion: Customised standards improve the prediction of adverse neonatal outcome. The association between SGA and adverse outcome is independent of the gestational age at delivery.

  • NICU, neonatal intensive care unit
  • SGA, small for gestational age
  • fetal growth restriction
  • neonatal morbidity
  • birthweight
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Footnotes

  • Published Online First 24 January 2007

  • Competing interests: None.

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