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Palliation bias is being overlooked in neonatal hypothermia trials
  1. A J A Ziino
  1. Department of Neonatology, Sunnybrook and Women’s College Health Sciences Centre, Toronto, Canada
  1. Correspondence to:
    A J A Ziino
    Department of Neonatology, Sunnybrook and Women’s College Health Science Centre, Toronto, Canada;adrianziino{at}rogers.com

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I thank Edwards and Azzopardi for their review1 of the trials on therapeutic hypothermia after perinatal asphyxia.2–4 Unfortunately, the evaluation of data quality fails to acknowledge a major shortcoming common to all three reported trials—“palliation bias”. A clear palliation bias in the …

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