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Pooling of trials is not appropriate in the case of heterogeneity
  1. C W Bollen,
  2. C S P M Uiterwaal,
  3. A J van Vught
  1. University Medical Centre, Lundlaan 6, Utrecht, the Netherlands; c.w.bollen@umcutrecht.nl

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    We read with great interest the systematic review by Thome et al1 on the elective use of high frequency ventilation compared with conventional mechanical ventilation in preterm infants. Thome et al included 17 randomised trials and stated that, unlike previous meta-analyses, they did not find significant benefits in pulmonary outcome. They also referred to our published cumulative meta-analysis.2 However, we would like to point to the fact that, in our meta-analysis, we reported the same finding, but we restricted …

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