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Does antenatal pelvic dilation predict renal scarring?
  1. N D Plant1,
  2. R J Hornung1,
  3. M G Coulthard1,
  4. M J Keir3,
  5. J N S Matthews4,
  6. S C Robson2
  1. 1Department of Paediatric Nephrology, Royal Victoria Infirmary, Newcastle NE1 4LP, UK
  2. 2Department of Fetal Medicine, Royal Victoria Infirmary
  3. 3Department of Medical Physics, Royal Victoria Infirmary
  4. 4Department of Medical Statistics, University of Newcastle, Newcastle NE1 7RU
  1. Correspondence to:
    Dr Plant
    Department of Paediatric Nephrology, Royal Manchester Children’s Hospital, Hospital Road, Pendlebury, Manchester M27 4HA, UK; nick.plantcmmc.nhs.uk

Abstract

Moderate antenatal renal pelvic dilation (5–15 mm) may suggest vesicoureteric reflux, but it is not known to predict renal scarring. Dimercaptosuccinic acid scans on such children aged over 4 years showed a scarring rate (0/133 boys, 1/56 girls) similar to our local population. Investigation and treatment of moderate dilation may not be required.

  • antenatal
  • renal pelvic dilation
  • renal scarring
  • urinary tract infection
  • vesicoureteric reflux

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The antenatal anteroposterior renal pelvic diameter on ultrasound measurement is normally up to 5 mm.1 Values above 15 mm suggest obstruction,2 but moderate dilation of 5–15 mm may be associated with postnatal vesicoureteric reflux.3 Because reflux and urinary tract infections may lead to preventable renal scarring, some centres perform micturating cystography in these newborns. However, the assumed relation between children in whom moderate antenatal pelvic dilation is identified and development of subsequent renal scarring has never been confirmed.

METHODS

Because renal scarring virtually always begins before the 4th birthday,4 we performed dimercaptosuccinic acid scans on children over 4 years old who were known to have had moderate antenatal dilation on at least one side. Cases were recruited from two local antenatal databases that were acquired before the link between moderate renal pelvic dilation and vesicoureteric reflux had been postulated, so there had been no clinical follow up. Fetuses with additional abnormalities were excluded, as were children who had ever taken long term prophylactic antibiotics. We asked their general practitioners for evidence of previous microbiologically proven urine infections. Children who had already had a dimercaptosuccinic acid scan after their 4th birthday were included, but not rescanned. We compared their urine infection and kidney scarring rates with our published local values.5

Ethics approval was obtained from the Northern and Yorkshire Multicentre Research Ethics Committee.

RESULTS AND DISCUSSION

Of 239 children identified from the databases, 10 had already had dimercaptosuccinic acid scans, and we performed 179 more on children with a mean age of 7.4 years (range 4.1–13.6). Unilateral renal pelvic dilation had been identified in 101 children and bilateral in 88. The 50 children who did not participate were similar to those who did, suggesting that their exclusion did not cause important bias (table 1).

Table 1

 Results of 239 children with moderate antenatal renal pelvic dilation

The previously described male preponderance of moderate dilation was noted.1,3 Only a single segment kidney scar was noted, in a girl who had already been scanned after proven urinary tract infections. The scarring rate was 0/133 (0%, 95% confidence interval (CI) 0 to 2.8) for boys and 1/56 (1.8%, 95% CI 0.3 to 9.4) for girls. The corresponding values for our control population were 0.17% for boys and 0.52% for girls. We assessed these data using a Bayesian approach with a prior distribution assumed for the population scarring rate: the mean given by the population rate and the variance controlled by a parameter, N. Values of N near 1 correspond to greater prior uncertainty than values near 100, for example. The probability of obtaining 0 scars in a sample of 133 boys or 0 or 1 scars in a sample of 56 girls can be computed from the predictive distribution for a wide range of values of N. If all these values are unsurprising, it is reasonable to believe no evidence has been found that children with moderate antenatal dilation have higher scarring rates than the general population. The probability of 0 boys scarring was between 0.88 and 0.95, and for 0 or 1 girls scarring was between 0.93 and 0.95, indicating that the scarring rates among children with moderate antenatal renal pelvic dilation were not significantly different from our local population.

Ten of the 133 study boys (7.5%, 95% CI 4.1 to 13.3) and seven of 56 girls (12.5%, 95% CI 6.2 to 23.6) had urine infections, compared with population rates of 3.1% and 8.0% respectively. The probability of 10 or fewer infections among 133 boys was 0.88 to 0.96 for a wide range of N, and for seven or fewer among 56 girls was 0.79 to 0.87, so these rates were not unusual compared with our population controls.

Our data indicate that moderate antenatal renal pelvic dilation of 5–15 mm is not a marker for an increased rate of urine infection or renal scarring, and suggests that it is inappropriate to perform cystograms on these babies as newborns.

Acknowledgments

This research was supported by a grant from the Newcastle University Hospitals Special Trustees. We thank Marjorie Renwick, Robyn Marley, Judith Rankin, and John Scott for their help with the NorCAS database. We are also grateful to the general practitioners and paediatricians who provided information on patients.

REFERENCES

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Footnotes

  • Competing interests: none declared

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