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Arch Dis Child Fetal Neonatal Ed 2001;84:F134-F135 doi:10.1136/fn.84.2.F134
  • Short report

Neonatal paroxetine withdrawal syndrome

  1. J A Stiskala,
  2. N Kulinb,
  3. G Korenb,
  4. T Hob,
  5. S Itob
  1. aDivision of Neonatology, Morristown Memorial Hospital, Morristown, New Jersey, USA, bDivision of Clinical Pharmacology and Toxicology, Motherisk Program, Department of Pediatrics, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada M5G 1X8
  1. Dr Itoito{at}sickkids.on.ca
  • Accepted 31 October 2000

Abstract

Four term neonates presented with symptoms such as jitteriness and necrotising enterocolitis after paroxetine exposure in utero.

  • Paroxetine withdrawal syndrome was suspected in four neonates exposed to the drug in utero at maternal doses ranging from 20 to 120 mg/day

  • The symptoms and abnormalities included, but were not limited to, jitteriness, vomiting, irritability, hypoglycaemia, and necrotising enterocolitis

  • Close observation is warranted for neonates exposed to paroxetine in utero

Footnotes

    Responses to this article

    • Neonatal paroxetine withdrawal syndrome or actually serotonin syndrome? - Authors' response
      • Joseph Stiskal
      Arch Dis Child - Fetal Neonatal Ed published online April 12, 2001
    • Neonatal paroxetine withdrawal syndrome or actually serotonin syndrome?
      • Geoffrey K Isbister
      Arch Dis Child - Fetal Neonatal Ed published online March 24, 2001

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