Giant steps forward in neonatal hyperinsulinaemia

Few neonatologists can have failed to realise that progress in neonatal hyperinsulinaemia (HI) has been rapid since the genes associated with HI were first identified in 1994–95. All will appreciate the clarity and depth of the reviews published in this issue. Progress has been achieved as a result of effective collaboration between many laboratories, reflected in the authorship, and this research community deserve credit for working together in this way. Glaser et al (page F79) explain the pathways of insulin secretion and the possible genetic mutations in a way we can all understand, and teach us about a new genetic syndrome with hyperinsulinism and hyperammonaemia. Shepherd and colleagues in Sheffield (page F87) explain the physiology of insulin release with …