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CD40 ligand expression on the surface of colostral T cells.
  1. A. Bertotto,
  2. G. Castellucci,
  3. M. Radicioni,
  4. M. Bartolucci,
  5. R. Vaccaro
  1. Department of Paediatrics, Perugia University Medical School, Italy.

    Abstract

    The proportion of T lymphocytes, mainly CD4 positive, co-expressing the CD40 ligand (CD40-L) was significantly greater (P = 0.001) in the colostrum of 10 breast-feeding mothers than in either autologous or heterologous blood. This surface glycoprotein is a T cell molecule involved in B cell isotype switching and immunoglobulin production with its natural counter-receptor, CD40, expressed by both adult and infant B lymphocytes. As the T cells of newborn infants fail to express the CD40-L when stimulated in vitro, the in vivo upregulation on milk T lymphocytes may be one of the mechanisms through which the mother transfers immune protection to the suckling infant.

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