AIMS--To determine the effectiveness of intravenous immunoglobulin administration to premature infants in the prevention and/or treatment of bacterial infection. METHODS--Computer searches of MEDLINE, EMBASE, SCISEARCH and Oxford Database of Perinatal Trials were made. Two independent researchers applied inclusion criteria of: randomised controlled trial; premature and/or low birthweight infant; use of intravenous immunoglobulin; and infection or mortality. Nineteen of 44 identified studies fulfilled these criteria. Study quality was assessed and information on study population, intervention, and outcomes were collected. RESULTS--Studies were divided into prophylaxis or treatment; results were tabulated for infection, sepsis, and death from all causes. For 17 studies of prophylaxis (n = 5245), the relative risk and confidence interval were, for proved infection 0.81, 0.67-0.97; for sepsis 0.87, 0.66-1.13; for death from all causes 0.85, 0.64-1.14. Some outcome results were heterogeneous. Two treatment studies showed no reduction in mortality when combined. CONCLUSIONS--Routine administration of intravenous immunoglobulin to preterm infants is not recommended.
Statistics from Altmetric.com
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.