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Review
The roles of drug therapy given via the endotracheal tube to neonates
  1. Anne Greenough1,2,
  2. Niovi Papalexopoulou1
  1. 1Division of Asthma, Allergy and Lung Biology, MRC & Asthma UK Centre in Allergic Mechanisms of Asthma, King's College London, London, UK
  2. 2NIHR Biomedical Research Centre at Guy's and St Thomas’ NHS Foundation Trust and King's College London, London, UK
  1. Correspondence to Professor Anne Greenough, Neonatal Intensive Care Unit, 4th Floor Golden Jubilee Wing, King's College Hospital, Denmark Hill, London SE5 9RS, UK; anne.greenough{at}kcl.ac.uk

Abstract

Many drugs are given to intubated neonates by the inhalation route. The optimum aerosol delivery system, however, has not been identified and there are many challenges in delivering drugs effectively to the lower airways of intubated neonates. The effectiveness of surfactant in prematurely born infants and nitric oxide has been robustly investigated. Other drugs are being used on very limited evidence.

  • Neonate
  • Surfactant
  • Pulmonary vasodilators
  • Bronchodilators

https://doi.org/10.1136/archdischild-2016-311711

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    Footnotes

    • Competing interests None declared.

    • Provenance and peer review Commissioned; externally peer reviewed.

    • Data sharing statement The data can be open for sharing if required.