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Oxygen saturation targets: outcome at 18 to 24 months

Between them, the BOOST-II, COT and SUPPORT trials have improved our understanding of appropriate oxygen saturation targets, or so we like to believe. In the latest meta-analytic offering (Pediatrics doi:10.1542/peds.2016-1609), Manja et al have evaluated the composite outcome of death or disability at 18 to 24 months in 4751 subjects; the difference between this and other meta-analyses being the use of a standardised cut-off for defining disability. Intriguingly, using this standardised definition there was no difference in the composite outcome between the higher and lower oxygen saturation target ranges. Also, the mortality advantage for the higher target range was dependent on whether the analysis was confined to the original or revised pulse oximeter algorithm, so questions about the relevance and validity of this result will ensure that the debate keeps alive for a long time yet.

Preterm hypoglycaemia at 18 years

In spite of several high quality cohort studies which failed to find any measurable effect of hypoglycaemia among preterm babies, many still find this hard to swallow. So it is important to keep looking, but the latest data from Goode et al. (Pediatrics doi:10.1542/peds.2016-1424) …

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