Objective To determine the distending pressure needed to achieve sufficient tidal volume (VT) delivery during continuous chest compressions (CC) superimposed by sustained inflation (SI) (CC+SI).
Design Randomised animal/manikin trial.
Setting University laboratory.
Subjects Cadaver piglets/manikin.
Interventions SI distending pressures of 5, 10, 15, 20, 25 and 30 cm H2O were delivered in random order during CC+SI for 2 min each.
Main outcome measures VT, gas flow and airway pressure. Spearman's r for distending pressure and VT.
Results Distending pressure and VT correlated in cadaver piglets (r=0.83, p<0.001), manikin (r=0.98, p<0.001) and combined data (r=0.49, p<0.001). VT was delivered during chest recoil during CC in both models. In cadaver piglets, a distending pressure ∼25 cm H2O was needed to achieve an adequate VT.
Conclusions Chest recoil generates VT depending on an adequate distending pressure. This has previously been demonstrated in adult animals. A pressure of ∼25 cm H2O is needed to achieve an adequate VT delivery.
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Contributors Conception and design: ALS, T-FL, ML, PYC, GMS. Collection and assembly of data: ALS, T-FL, ML, P-YC, GMS. Drafting of the article: ALS, GMS, P-YC. Critical revision of the article for important intellectual content: ALS, T-FL, ML, P-YC, GMS. Final approval of the article: ALS, T-FL, ML, P-YC, GMS.
Funding Canadian Institutes of Health Research, 10.13039/501100000024, MOP-CIA-299111.
Competing interests None declared.
Provenance and peer review Not commissioned; externally peer reviewed.
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