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Serial C reactive protein values predict sensitivity of organisms to empirical antibiotics in neonates: a nested case–control study
  1. Sandeep Patil1,
  2. Sourabh Dutta1,
  3. Savita Verma Attri1,
  4. Pallab Ray2,
  5. Praveen Kumar1
  1. 1Department of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh, India
  2. 2Department of Medical Microbiology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
  1. Correspondence to Professor Sourabh Dutta, Division of Neonatology, Department of Pediatrics, PGIMER, Sector 12, Chandigarh 160012, India; sourabhdutta{at}yahoo.co.in

Abstract

Background It is common clinical practice to repeat serum C reactive protein (CRP) estimation in the first 48 h after starting empirical antibiotics for neonatal sepsis. The change in CRP is believed to indicate whether the empirical antibiotics are appropriate or not, but there is little evidence to support this practice.

Methods This was a nested case–control study on neonates with suspected sepsis (clinical signs+baseline CRP >10 mg/L). We drew samples for serum CRP at baseline and at 24, 36 and 48 h after starting empirical antibiotics and stored them at −20°C. Those with positive blood cultures were enrolled into two groups: those who had received empirical antibiotics to which the organism was sensitive (‘sensitive’) and those who had received antibiotics to which the organism was resistant (‘resistant’). Stored samples of these subjects were assayed for CRP. Repeated CRP values were compared between groups by mixed linear models. We evaluated change in CRP from baseline as a diagnostic test for identifying empirical use of sensitive antibiotics.

Results We enrolled 45 and 44 subjects in ‘sensitive’ and ‘resistant’ groups, respectively. In the ‘resistant’ group, median CRP increased with time but decreased in the ‘sensitive’ group. Decline in CRP by 48 h identified the use of antibiotics to which the organism was sensitive with 89% sensitivity and 80% specificity.

Conclusions Serial CRP values in the first 48 h of antibiotic therapy help to predict whether the causative organism is sensitive to the empirical antibiotics administered.

  • Neonatology
  • Infectious Diseases

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Footnotes

  • Contributors SP was involved in designing the study, recruiting subjects, drawing the CRP samples, recording the data and writing the first draft of the manuscript. SD designed the study, analysed the data and wrote the manuscript. SVA performed the laboratory analysis of the CRP samples and contributed to the manuscript. PR performed the blood culture of the enrolled subjects and contributed to the manuscript. PK was involved in designing the study, supervising the conduct of the study and finalising the manuscript.

  • Competing interests None declared.

  • Ethics approval Intramural Institute ethics committee of the Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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