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Poractant-α is the most common surfactant in Europe:1 its recommended dose is 200 mg/kg, according to pharmacokinetic and clinical data.2 We hypothesised that the correct dose is not often followed at the bedside as some clinicians may be tempted to administrate a rounded dose. In fact, a recent multicentre randomised clinical trial has been based on a rounded dose, as the authors acknowledge among the study limitations.3
We conducted a retrospective (2011–2013), population-based, cohort study performed on the formally established neonatal network in Parisian area,4 following Strengthening the Reporting of Observational Studies in Epidemiology guidelines. Eligible babies were fulfilling the following conditions: (1) <37 weeks gestation, (2) respiratory distress syndrome defined as clinical distress needing oxygen and/or continuous positive airway pressure or mechanical ventilation with the typical radiological appearance, (3) surfactant administered in the …
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