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Targeted neonatal echocardiography (TNE) is widely used in the cardiovascular management of sick infants in neonatal intensive care unit (NICU).1 TNE should only be performed by operators who possess the knowledge and skills to acquire high-quality images in a structured manner, in order to formulate a diagnosis and medical recommendation. Suboptimal image quality due to agitation of the infant during a TNE may prolong scan time and result in errors in measurements and interpretation, leading to incorrect medical decisions. Oral glucose solutions are recommended to reduce procedure-related stress in infants.2 However, there are no data supporting this intervention in the context of the conductance of TNE. Anecdotally, many neonatologist sonographers across the globe have adopted the routine use of oral glucose to reduce agitation and facilitate image acquisition during a TNE, despite a lack of supporting scientific evidence.
To determine whether oral glucose is effective in reducing agitation during a TNE, 104 infants born between 26 …
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