Arch. Dis. Child. Fetal Neonatal Ed.. Published Online First: 3 September 2007. doi:10.1136/adc.2007.121962
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Systemic antifungal prophylaxis for very-low-birth-weight infants: systematic review
1 Wishaw Hospital, United Kingdom
2 Christchurch Women's Hospital, New Zealand
3 Australian National University, Australia
* To whom correspondence should be addressed. E-mail: william.mcguire{at}act.gov.au.
Accepted 8 August 2007
Abstract
Systematic review and meta-analysis of four randomised controlled trials suggests that prophylactic fluconazole reduces the incidence of invasive fungal infection in very-low-birth-weight infants. Further trials are needed to provide more precise estimates of effect size, and to assess the effect on mortality, neurodevelopment, and the emergence of antifungal resistance.
Keywords: antifungal prophylaxis, very-low-birth-weight
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