Arch. Dis. Child. Fetal Neonatal Ed.. Published Online First: 17 August 2007. doi:10.1136/adc.2006.110874
Original articles |
Bone status of 5-8 year olds, treated with dexamethasone for chronic lung disease of prematurity
1 Department of Paediatrics, Saint Mary's Hospital for Women & Children, United Kingdom
2 Biostatistics Group, School of Epidemiology & Health Sciences, Uni of Manchester, United Kingdom
3 Department of Neonatology, St. Mary's Hospital for Women & Children, United Kingdom
4 Clinical Radiology, Imaging Science & Biomed Engineering, Uni of Manchester, United Kingdom
* To whom correspondence should be addressed. E-mail: zulf.mughal{at}cmmc.nhs.uk.
Accepted 5 August 2007
Abstract
Total body bone mineral content and bone mineral apparent density of the lumbar spine were lower in children whose chronic lung disease was treated with dexamethasone (Dx) in the neonatal period, compared to pre-term controls. Therefore, Dx treatment in the neonatal period appears to cause impairment of mineralisation, which persists into childhood.
Keywords: DXA, Dexamethasone, bone mineral density, chronic lung disease of prematurity, pQCT
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