ABSTRACTS
Poster presentations - Fetal medicine
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THE ROLE OF THE THYROID HORMONE MONOCARBOXYLATE TRANSPORTER 8 IN HUMAN PLACENTAL DEVELOPMENT
E. Vasilopoulou, L. Loubière, C. McCabe, J. Franklyn, M. Kilby, S. Chan. University of Birmingham, Birmingham, West Midlands, UK
Thyroid hormones (TH) are important for fetoplacental development. Monocarboxylate transporter 8 (MCT8) is a potent plasma membrane TH transporter expressed in the human placenta from 6 weeks of gestation and its expression increases significantly with advancing gestational age. MCT8 expression reduces proliferation in choriocarcinoma-like (JEG-3) cells. In order to investigate the role of MCT8 in human placental development, we transfected human wild type MCT8 or "knocked-down" endogenous MCT8 expression in primary cytotrophoblast cells from term placenta (CTs) and extravillous trophoblast (EVT)-like SGHPL-4 cells followed by 48 h treatment with 0 or 10 nM triiodothyronine (T3). Overexpression of MCT8 decreased viability (MTT assay) of CTs by 20% both in the presence (p<0.001) and absence (p<0.01) of T3, while downregulation of MCT8 expression resulted in increased CT viability by 20% (p<0.01 at 0
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