ORAL PRESENTATIONS
Session 8
Session 8A BMFMS: Maternal Medicine
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8.1 VASCULAR ENDOTHELIAL GROWTH FACTOR165B AND PRE-ECLAMPSIA
V. L. Bills, D. O. Bates1, P. W. Soothill2. 1University of Bristol, Bristol, UK, 2St Michael’s Hospital, Bristol, UK
Introduction: The vascular endothelial growth factor (VEGF) family of glycoproteins plays a key role in the regulation of angiogenesis, vascular permeability and vasodilatation, with high levels occurring in pre-eclamptic plasma. Novel VEGF165b isoforms, formed by alternatively splicing exon 8 of the VEGF gene, are not described in pregnancy. VEGF165b inhibits conventional VEGF165-mediated vasodilatation and angiogenesis and increases vessel permeability.
Materials and Methods: We developed an ELISA to measure plasma VEGF165b concentrations using a VEGF165b-specific capture antibody (R&D MAB3045) and a biotinylated pan-VEGF detection antibody. The ELISA is sensitive to 30 pg/ml. We quantified soluble fms-like tyrosine kinase (sFlt1) and soluble endoglin (sEng) concentrations in the same plasma by ELISA.
Results: Pre-eclampsia is associated with an eightfold increase in plasma VEGF165b from
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