ORAL PRESENTATIONS
Session 9
Session 9B BAPM/NNS: Nutrition
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9.6 DIFFERENTIAL EFFECTS OF MATERNAL NUTRIENT RESTRICTION ON INFLAMMATION IN RENAL AND ADIPOSE TISSUE IN OBESE JUVENILE OFFSPRING: THE ROLE OF TLR4 AND CCR2
D. Sharkey, P. Williams, P. Bos, S. Sebert, D. Gardner, M. Symonds, H. Budge. University of Nottingham, Nottingham, UK
Introduction: Obesity is associated with a chronic inflammatory state. Key proinflammatory genes involved include Toll-like receptor 4 (TLR4) and chemokine receptor 2 (CCR2). We have previously shown, in sheep, that early-to-mid maternal nutrient restriction protects the kidney from the deleterious effects of juvenile obesity. The extent to which alterations, or differential tissue regulation, occur in these key genes after adolescent onset obesity is unknown. We examined the combined effects of maternal nutrient restriction during pregnancy and early-onset obesity on their distribution.
Methods: Eighteen pregnant sheep were randomly assigned to a normal (C, 7 MJ/day, n = 8) or nutrient restricted diet (NR, 3.5 MJ/day, n = 10) from days 30 to 80 gestation (term 147 days). After weaning, offspring had restricted activity and increased energy-dense food to promote obesity.
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