ORAL PRESENTATIONS
Session 9
Session 9A BMFMS: Labour and Delivery
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9.1 MYOMETRIAL CONTRACTILITY STUDIES IN DIABETIC PREGNANT WOMEN
S. Alqahtani1, F. Dawood2, S. Quenby1, S. Wray1. 1University of Liverpool, Liverpool, UK, 2Liverpool Women’s NHS Foundation Trust, Liverpool, UK
Several studies worldwide have shown a higher Caesarean section rate in diabetic compared with non-diabetic women. Local audit conducted at our hospital revealed an emergency Caesarean section rate of 37.4% compared with 13.2% for non-diabetic women. We have investigated whether there is an intrinsic contractility problem in the myometria of pregnant diabetic women.
Methods: Myometrial biopsies were obtained during term elective Caesarean section from 20 diabetic and 68 non-diabetic women and were subjected to in-vitro laboratory testing. All the diabetic women had good antenatal glycaemic control. Contractility was measured simultaneously with intracellular calcium signalling using fluorescent Indo-1. Contractility was also measured in 0-glucose solutions and with the addition of 700 pM insulin. Myometrial glycogen content was measured in millimoles.
Results: The entire set of
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