ORAL PRESENTATIONS
Session 4
Session 4A BMFMS: Fetal Medicine
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4.1 LOCAL DELIVERY OF VASCULAR ENDOTHELIAL GROWTH FACTOR ADENOVIRUS TO THE UTERINE ARTERY INCREASES VASORELAXATION AND BLOOD FLOW TO THE PREGNANT SHEEP UTERUS LONG TERM
K. Abi Nader1, B. Torondel2, V. Wigley1, I. Zachary2, J. Martin2, M. Boyd3, T. Cook4, C. H. Rodeck1, D. M. Peebles1, A. L. David1. 1Institute for Women’s Health, University College London, London, UK, 2Department of Cardiovascular Medicine, University College London, London, UK, 3Biological Sciences Unit, Royal Veterinary College, London, UK, 4Department of Pathology, Imperial College, London, UK
Introduction: Impaired uteroplacental perfusion causes fetal growth restriction. Our work aims to treat fetal growth restriction by increasing uteroplacental perfusion. Using Doppler ultrasound we previously showed significantly increased uterine blood flow (UBF) 5 days after adenovirus vector-mediated overexpression of vascular endothelial growth factor (VEGF) in the uterine artery. This study investigated the long-term effect of this vector.
Methods: We implanted ultrasonic flow probes (Transonic Inc, USA) around both uterine arteries in mid-gestation pregnant sheep (n = 6, 90 days of gestation,
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