Archives of Disease in Childhood - Fetal and Neonatal Edition 2007;92:F435-F437
LEADING ARTICLES
Neurology of congenital heart disease
Neurology of congenital heart disease: insight from brain imaging
1 Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada
2 Department of Pediatrics, University of California, San Francisco, California, USA
Dr Steven P Miller, University of British Columbia, BC Children’s Hospital, Division of Neurology, K3-180, 4480 Oak Street, Vancouver BC V6H 3V4 Canada; smiller6@cw.bc.ca
Accepted 28 June 2007
Understanding of the specific pathophysiology of acquired brain injury in infants with CHD will help optimise treatment and brain protection strategies
Abbreviations: CHD, congenital heart disease; TGA, transposition of the great arteries
| The first 150 words of the full text of this article appear below. |
Congenital heart disease (CHD) is a common cause of childhood morbidity, occurring in 6–8/1000 live births, with up to 50% of these children requiring open-heart surgery to correct their defect.1 2 Most forms of CHD can now be definitively repaired with neonatal surgery resulting in good cardiac function. However, neurological deficits are common, particularly in infants. Given the burden of neurodevelopmental impairment following neonatal cardiac surgery, this article will discuss:
- the timing of brain injury in newborns with CHD;
- how the pattern of brain abnormalities on imaging studies, such as stroke or white matter injury, informs etiology;
- the surprising predominance of white matter injury in term newborns with CHD.
NEURODEVELOPMENTAL ABNORMALITIES ARE COMMON IN INFANTS WITH CHD
CHD refers to a variety of malformations of the heart present at birth, and includes both cyanotic and acyanotic types. A seminal study of two forms of cardiopulmonary bypass for the correction of transposition of the great
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
Relevant Article
- Fantoms
- Martin Ward Platt
Arch. Dis. Child. Fetal Neonatal Ed. 2007 92: F423.[Extract] [Full Text] [PDF]
This article has been cited by other articles:
-
Watanabe, K., Matsui, M., Matsuzawa, J., Tanaka, C., Noguchi, K., Yoshimura, N., Hongo, K., Ishiguro, M., Wanatabe, S., Hirono, K., Uese, K., Ichida, F., Origasa, H., Nakazawa, J., Oshima, Y., Miyawaki, T., Matsuzaki, T., Yagihara, T., Bilker, W., Gur, R. C.
(2009). Impaired neuroanatomic development in infants with congenital heart disease.. J. Thorac. Cardiovasc. Surg.
137: 146-153
[Abstract] [Full Text]
- Full Text
- Full Text (PDF)
-
All Versions of this Article:
adc.2006.108845v1
92/6/F435 most recent - Submit a response
- Alert me when this article is cited
- Alert me when eLetters are posted
- Alert me if a correction is posted
- Citation Map
Services
- Email this link to a friend
- Similar articles in ADC Online
- Similar articles in PubMed
- Add article to my folders
- Download to citation manager
- Request Permissions
Citing Articles
Google Scholar
PubMed
Topic Collections
-
Child health
-
Drugs: cardiovascular system
-
Congenital heart disease
-
Child and adolescent psychiatry (paedatrics)
-
Trauma
- Relevant Article
Bookmark with
Register for free content
The full back archive is now available for all BMJ Journals. Institutional subscribers may access the entire archive as part of their subscription. Personal subscribers will also have access to all content when logged in. Non-subscribers who register have free access to all articles published before 2006 right back to volume 1 issue 1. Register here to access the free archive of all BMJ Journals.
Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.
