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To intubate or not—that is the question: continuous positive airway pressure versus surfactant and extremely low birthweight infants

Correspondence to:
Correspondence to:
N Finer
Department of Paediatrics/Neonatology, UCSD Medical Centre, 200 West Arbor Drive No 8774, San Diego, CA 92103-8774, USA;nfiner@ucsd.edu

The first 150 words of the full text of this article appear below.

There is currently a great dilemma regarding the early management of extremely low birthweight (ELBW) infants, which involves the use of continuous positive airway pressure (CPAP) after delivery compared with the use of prophylactic or early surfactant. Although there is good evidence that prophylactic and early surfactants reduce mortality and respiratory morbidity,^1–4 few of these studies had large numbers of the smallest babies who are the longest-term residents of our neonatal intensive care units; also, none of the studies randomised infants in the placebo or control group to treatment with early CPAP. In addition, surfactant treatment may be associated with a lowered rate of milder disabilities at 1 year of age.⁵ The use of mechanical ventilation, especially in the first few days of life, seems to considerably increase the risk for bronchopulmonary dysplasia as defined by the need for oxygen at 36 weeks,^6,7 and the incidence . . . [Full text of this article]

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Sustainable use of continuous positive airway pressure in extremely preterm infants during the first week after delivery

C Booth, M H Premkumar, A Yannoulis, M Thomson, M Harrison, and A D Edwards
Arch. Dis. Child. Fetal Neonatal Ed. 2006 91: F398-F402. [Abstract] [Full Text] [PDF]

This article has been cited by other articles:

				E. C. Eichenwald and A. R. Stark Management and Outcomes of Very Low Birth Weight N. Engl. J. Med., April 17, 2008; 358(16): 1700 - 1711. [Full Text] [PDF]