LETTER
Plasma leptin, insulin, and neuropeptide Y response to feeding in newborn infants
1 Department of Pediatric and Surgery Sciences, Division of Neonatology, University of Messina, Messina, Italy
2 Department of Radiologic Sciences, University of Messina
Correspondence to:
Correspondence to:
Professor Gemelli
Divisione di Neonatologia, Policlinico Università di Messina, 98100 Messina, Italy; Marina.Gemelli@unime.it
Keywords: insulin; leptin; neuropeptide; breast feeding
| The first 150 words of the full text of this article appear below. |
Although the functions and regulation of leptin, insulin, and neuropeptide Y (NPY) are well studied, their role and regulatory mechanisms in neonates are poorly understood.
We have reported that, compared with umbilical concentrations, on the 4th day of life fasting plasma leptin and insulin concentrations are significantly decreased, and plasma NPY concentrations increased.1 The effects of feeding on plasma concentrations of these hormones are controversial2,3 or have not been studied.
We have investigated the effects of breast feeding on plasma concentrations of leptin, insulin, and NPY in 30 healthy, full term neonates, exclusively breast fed, on the 4th day of life.
At 30 minutes after breast feeding, the mean (SD) plasma concentrations of leptin and insulin increased (leptin from 4.91 (6.05) to 9.85 (8.09) ng/ml (p<0.001), and insulin from 3.12 (1.24) to 9.41 (6.06) µU/ml (p<0.001)), whereas NPY did not show any significant change (73.87 (29.22) v 69.37 (26.52) pmol/l).
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