LETTER
Neonatal effects of exposure to selective serotonin reuptake inhibitors during pregnancy
1 Department of Paediatrics, Canisius-Wilhelmina Hospital, PO Box 9015, 6500 GS Nijmegen, the Netherlands
2 Department of Clinical Chemical Analysis, Canisius-Wilhelmina Hospital
Correspondence to:
Correspondence to:
Dr Semmekrot
B.Semmekrot@cwz.nl
Keywords: paroxetine; fluoxetine; sertraline; selective serotonin reuptake inhibitors; pregnancy
| The first 150 words of the full text of this article appear below. |
Selective serotonin reuptake inhibitors (SSRIs) are often prescribed during pregnancy.
It has long been debated whether adverse neonatal effects described after maternal SSRI use1–4 are caused by serotonin toxicity or withdrawal.5 Recently, the information of a database analysis of 93 suspected cases of SSRI induced neonatal withdrawal has been regarded as enough information to confirm a possible causal relation.6
We describe six infants with neonatal symptoms after maternal SSRI use. Table 1
summarises data from these infants. Mothers in cases 1 and 4 used multiple drugs during pregnancy. Because neonatal withdrawal to clorazepate has been described as neurological depression, this agent may have played an additional role in the initial symptoms in case 1. Neither oxcarbazepine nor thyroxine are known to cause neonatal abstinence. Gastro-oesophageal reflux, observed in case 1, may contribute to feeding problems, but the infant’s symptoms decreased before the start of anti-reflux medication, suggesting multicausality.
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Table 1 Patient data, |
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