© 2005 Archives of Disease in Childhood Fetal and Neonatal Edition
PERSPECTIVE
Etamsylate
Etamsylate for prevention of periventricular haemorrhage
Correspondence to:
Correspondence to:
Dr Hunt
Department of Neonatal Medicine, Level 2, Royal Children’s Hospital, Flemington Road, Parkville, VIC 3052, Australia; rod.hunt@rch.org.au
A perspective on the paper by Schulte et al (see page 31)
Keywords: etamsylate; periventricular haemorrhage; neurodevelopmental outcome
| The first 150 words of the full text of this article appear below. |
Despite the many advances of newborn intensive care over the past 20 years, periventricular haemorrhage (PVH) remains a significant cause of morbidity and mortality for the preterm infant. About 15% of infants with birth weight less than 1500 g develop PVH,1 and its presence significantly increases the risk of neurodevelopmental impairment.
New insights have been gained into the pathophysiology of PVH. The germinal matrix, a fragile network of blood vessels lining the ventricular system, is prone to bleeding in the preterm infant. The beagle puppy model of PVH has provided insight into our current understanding of the pathogenetic role of ischaemia and reperfusion.2 In the human preterm infant, depression of cerebral blood flow, associated with initial reduction in myocardial performance and presence of a patent ductus arteriosus, provides an environment in which ischaemia and reperfusion are likely, and PVH occurs more commonly under these circumstances.3
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