Letters to the editor
Low soluble FcRIII receptor demonstrates reduced neutrophil reserves in preterm neonates
| The first 150 words of the full text of this article appear below. |
EDITOR
Studies of human neonate
granulopoiesis have been hampered by the lack of a marker of overall
neutrophil cell mass. Assumptions about neonate granulopoiesis have
therefore largely been extrapolated from rat data. Direct measurement
of total neutrophil cell mass (in terms of neutrophils per g body
weight) in newborn rats has shown that they have about one quarter the
neutrophil mass of adult animals and that their neutrophil mass
increases to adult levels by the time they are 4 weeks
old.1 In addition, newborn rodents do not have the reserve
pool of quiescent granulocyte progenitors, as found in adults, to
recruit into production during sepsis. Circumstantial evidence for a
similar immaturity of neutrophil production in human neonates comes
from the low proportion of quiescent progenitors in cord
blood2 and the frequent occurrence of postnatal
neutropenia in preterm infants. Some additional insight comes from a
study of mid-trimester abortuses,3 which showed
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