Archives of Disease in Childhood - Fetal and Neonatal Edition 2008;93:F58-F63
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Postnatal hydrocortisone treatment for chronic lung disease in the preterm newborn and long-term neurodevelopmental follow-up
1 Department of Neonatology, University Medical Center Utrecht/Wilhelmina Children’s Hospital, Utrecht, The Netherlands
2 Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
Dr K J Rademaker, Department of Neonatology, KE 04.123.1, University Medical Center Utrecht/Wilhelmina Children’s Hospital, PO Box 85090, 3508 AB Utrecht, The Netherlands; k.rademaker{at}umcutrecht.nl
The benefits versus the risks of postnatal administration of steroids in preterm-born infants are still debatable. This review examines the literature on postnatal hydrocortisone treatment for chronic lung disease (CLD) in preterm-born infants with a particular focus on the effects of such treatment on long-term neurodevelopmental outcomes. Quantitative published evidence does not point to a clear advantage of treatment with hydrocortisone over dexamethasone with regard to the impact on long-term neurological outcomes. However, in the absence of a randomised comparison, a consensus may soon have to be reached on the basis of the best available evidence whether hydrocortisone should replace dexamethasone in the treatment of CLD.
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This article has been cited by other articles:
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Cambonie, G, Mesnage, R, Milesi, C, Rideau, A, Veyrac, C, Picaud, J-C
(2009). Hydrocortisone treatment for severe evolving bronchopulmonary dysplasia and cerebral haemodynamics. Arch. Dis. Child. Fetal Neonatal Ed.
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