REVIEW

Impact of common genetic variation on neonatal disease and outcome

David Harding

Correspondence to:
David Harding, University of Bristol, D Level, St Michael’s Hospital, Bristol BS2 8EG, UK; david.harding{at}bristol.ac.uk

The main aim of identifying gene–environment interactions is to provide insight into mechanisms of disease development and to identify patients with an inherent vulnerability to certain conditions. This in turn may allow patients to be targeted with individualised treatment based on the knowledge of their inborn susceptibility to specific conditions. This review describes the possible effects of common genetic variation on outcome in various conditions affecting the neonate. It focuses predominantly on studies of positive association rather than non-association to illustrate this potential influence and to highlight the potential for further study and intervention. The shortcomings of published association studies and the place of such studies in future research are also discussed.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

Relevant Article

Fantoms

Ben Stenson
Arch. Dis. Child. Fetal Neonatal Ed. 2007 92: F329. [Extract] [Full Text] [PDF]

This article has been cited by other articles:

• Chauhan, M, Bombell, S, McGuire, W (2009). Tumour necrosis factor (-308A) polymorphism in very preterm infants with bronchopulmonary dysplasia: a meta-analysis. Arch. Dis. Child. Fetal Neonatal Ed. 94: F257-F259 [Abstract] [Full Text]  
• Henderson, G, Craig, S, Baier, R J, Helps, N, Brocklehurst, P, McGuire, W (2009). Cytokine gene polymorphisms in preterm infants with necrotising enterocolitis: genetic association study. Arch. Dis. Child. Fetal Neonatal Ed. 94: F124-F128 [Abstract] [Full Text]  
• Chauhan, M, McGuire, W (2008). Interleukin-6 (-174C) polymorphism and the risk of sepsis in very low birth weight infants: meta-analysis. Arch. Dis. Child. Fetal Neonatal Ed. 93: F427-F429 [Abstract] [Full Text]