REVIEW

Contribution of inflammation to lung injury and development

S G Kallapur, A H Jobe

Cincinnati Children’s Hospital, Divisions of Pulmonary Biology and Neonatology, University of Cincinnati, Cincinnati, OH 45229, USA

Correspondence to:
Correspondence to:
Dr Kallapur
Cincinnati Children’s Hospital Medical Center, Division of Pulmonary Biology, 3333 Burnet Avenue, Cincinnati, OH 45229-3039, USA; Suhas.Kallapur{at}cchmc.org

Inflammation interferes with lung development in model systems and is present chronically in the lungs of preterm infants who develop bronchopulmonary dysplasia (BPD). Antenatal inflammation is very commonly associated with preterm deliveries, but there is generally minimal information about the duration, intensity, or organisms associated with chorioamnionitis. In preterm lamb models, chorioamnionitis causes a lung injury similar to BPD and also causes clinical lung maturation. Continuous exposure of the developing lung before and after delivery to inflammation may be central to the development of BPD.

Abbreviations: BPD, bronchopulmonary dysplasia; CPAP, continuous positive airway pressure; IL, interleukin; RDS, respiratory distress syndrome

Keywords: respiratory distress syndrome; bronchopulmonary dysplasia; cytokines; surfactant; mechanical ventilation

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

• Kallapur, S. G., Moss, T. J. M., Auten, R. L. Jr., Nitsos, I., Pillow, J. J., Kramer, B. W., Maeda, D. Y., Newnham, J. P., Ikegami, M., Jobe, A. H. (2009). IL-8 signaling does not mediate intra-amniotic LPS-induced inflammation and maturation in preterm fetal lamb lung. Am. J. Physiol. Lung Cell. Mol. Physiol. 297: L512-L519 [Abstract] [Full Text]  
• Chauhan, M, Bombell, S, McGuire, W (2009). Tumour necrosis factor (-308A) polymorphism in very preterm infants with bronchopulmonary dysplasia: a meta-analysis. Arch. Dis. Child. Fetal Neonatal Ed. 94: F257-F259 [Abstract] [Full Text]  
• Bhandari, A., Bhandari, V. (2009). Pitfalls, Problems, and Progress in Bronchopulmonary Dysplasia. Pediatrics 123: 1562-1573 [Abstract] [Full Text]  
• Cao, L., Wang, J., Tseu, I., Luo, D., Post, M. (2009). Maternal exposure to endotoxin delays alveolarization during postnatal rat lung development. Am. J. Physiol. Lung Cell. Mol. Physiol. 296: L726-L737 [Abstract] [Full Text]  
• Laughon, M., Allred, E. N., Bose, C., O'Shea, T. M., Van Marter, L. J., Ehrenkranz, R. A., Leviton, A., for the ELGAN Study Investigators, (2009). Patterns of Respiratory Disease During the First 2 Postnatal Weeks in Extremely Premature Infants. Pediatrics 123: 1124-1131 [Abstract] [Full Text]  
• Bassler, D., Stoll, B. J., Schmidt, B., Asztalos, E. V., Roberts, R. S., Robertson, C. M. T., Sauve, R. S., for the Trial of Indomethacin Prophylaxis in Prete, (2009). Using a Count of Neonatal Morbidities to Predict Poor Outcome in Extremely Low Birth Weight Infants: Added Role of Neonatal Infection. Pediatrics 123: 313-318 [Abstract] [Full Text]  
• Yoder, B. A., Albertine, K. H. (2008). Inflammation and Lung Disease in the Neonatal Period. NeoReviews 9: e447-e457 [Abstract] [Full Text]  
• Qiu, W., Zheng, L., Gu, H., Chen, D., Chen, Y. (2008). Comparison between adult and infant lung injury in a rabbit ischemia-reperfusion model.. J. Thorac. Cardiovasc. Surg. 136: 352-359 [Abstract] [Full Text]  
• Verlato, G., Cogo, P. E., Balzani, M., Gucciardi, A., Burattini, I., De Benedictis, F., Martiri, G., Carnielli, V. P. (2008). Surfactant Status in Preterm Neonates Recovering From Respiratory Distress Syndrome. Pediatrics 122: 102-108 [Abstract] [Full Text]  
• De Paepe, M. E., Gundavarapu, S., Tantravahi, U., Pepperell, J. R., Haley, S. A., Luks, F. I., Mao, Q. (2008). Fas-Ligand-Induced Apoptosis of Respiratory Epithelial Cells Causes Disruption of Postcanalicular Alveolar Development. Am. J. Pathol. 173: 42-56 [Abstract] [Full Text]  
• Friedrich, L., Pitrez, P. M. C., Stein, R. T., Goldani, M., Tepper, R., Jones, M. H. (2007). Growth Rate of Lung Function in Healthy Preterm Infants. Am. J. Respir. Crit. Care Med. 176: 1269-1273 [Abstract] [Full Text]