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Chitotriosidase in neonates with fungal and bacterial infections

¹ Neonatal Intensive Care Unit, General Hospital of Nikea, Piraeus, Greece
² Institute of Child Health, Agia Sophia Children’s Hospital, Athens, Greece
³ Mycology Reference Laboratory, Medical School, University of Athens, Athens, Greece

Correspondence to:
Correspondence to:
Helen Michelakakis
Department of Enzymology and Cellular Function, Institute of Child Health, Agia Sophia Children’s Hospital, 11527 Athens, Greece; inchildh{at}otenet.gr

ABSTRACT
Increased plasma and/or urine chitotriosidase activity was found in neonates with fungal infection changing in parallel with their clinical condition. Increased levels were also found in neonates with bacterial infection. Chitotriosidase activity increase is not a response specific to fungi, but serial assays could monitor the course of neonatal fungal infection.

Keywords: chitotriosidase; fungal-bacterial infection; neonates