ORIGINAL ARTICLE

Benefit of antenatal glucocorticoids according to the cause of very premature birth

L Foix-L’Helias^1,3, O Baud¹, R Lenclen², M Kaminski³, T Lacaze-Masmonteil¹

¹ Division of Neonatology, Antoine-Béclère University Hospital, Assistance Publique/Hôpitaux de Paris, Clamart, France
² Division of Neonatology, Poissy-Saint Germain Hospital, Poissy, France
³ Epidemiological Research Unit on Perinatal and Women’s Health, INSERM U149, Villejuif, France

Correspondence to:
Correspondence to:
Dr Lacaze-Masmonteil
Antoine-Béclère University Hospital, Assistance Publique/Hôpitaux de Paris, 157 rue de la porte de Trivaux, 92141 Clamart, Cedex, France; tlacaze{at}club-internet.fr

In this observational study performed in a large cohort of very preterm singletons, respiratory outcome was found to be strongly dependent on the cause of premature delivery. Although less apparent in infants born to mothers with chorioamnionitis, exposure to antenatal glucocorticoids remained significantly associated with a decrease in the incidence of respiratory distress syndrome after adjustment for the main cause of premature birth.

Abbreviations: AG, antenatal glucocorticoid; BPD, bronchopulmonary dysplasia; IUGR, intrauterine growth restriction; RDS, respiratory distress syndrome

Keywords: antenatal; glucocorticoids; bronchopulmonary dysplasia; premature birth; respiratory distress syndrome

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