© 2004 Archives of Disease in Childhood Fetal and Neonatal Edition
ORIGINAL ARTICLE
Suppressive effects of breast milk on oxidative DNA damage in very low birthweight infants
Department of Paediatrics, Juntendo University School of Medicine, Tokyo, Japan
Correspondence to:
Correspondence to:
Dr Shimizu
Department of Pediatrics, Juntendo University, School of Medicine, 2-1-1, Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan; tsimizut{at}aol.com
Background: Human milk contains many kinds of antioxidant and is considered to prevent diseases mediated by oxygen free radicals in very low birthweight (VLBW) infants.
Aims: To examine the antioxidant effects of breast milk in VLBW infants by determining urinary 8-hydroxydeoxyguanosine (8-OHdG) excretion, which is known to be a non-invasive marker for in vivo oxidative DNA damage.
Methods: Urinary 8-OHdG concentrations were measured in 15 breast fed and 14 formula fed VLBW infants at 2, 7, 14, and 28 days of age.
Results: Urinary 8-OHdG excretion at 14 and 28 days of age was significantly lower than at 2 and 7 days of age in the breast fed group, and significantly lower than in the formula fed group.
Conclusion: This is the first direct evidence of the antioxidant action of human milk in VLBW infants.
Keywords: antioxidants; 8-hydroxydeoxyguanosine; milk; oxygen free radicals; very low birthweight infants
Abbreviations: 8-OHdG, 8-hydroxydeoxyguanosine; VLBW, very low birth weight; NEC, necrotising enterocolitis; CLD, chronic lung disease; ROP, retinopathy of prematurity; IVH, intraventricular haemorrhage; ELISA, enzyme linked immunosorbent assay
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Arch. Dis. Child. Fetal Neonatal Ed. 2004 89: F96.
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