© 2002 Archives of Disease in Childhood Fetal and Neonatal Edition
CASE REPORT
Neonatal alloimmune thrombocytopenia with significant HLA antibodies
1 Department of Haematology, Manchester Children's Hospital, Pendlebury, Manchester M27 4HA, UK
2 Manchester Blood Centre, Plymouth Grove, Manchester, UK
Correspondence to:
Correspondence to:
Dr Grainger, Department of Haematology, Manchester Children's Hospital, Pendlebury, Manchester M27 4HA, UK;
jgrainger{at}bigfoot.com
A case of neonatal alloimmune thrombocytopenia (NAIT) secondary to human platelet antigen (HPA)-1a antibodies is reported. Additional multispecific HLA antibodies rendered volunteer donor platelet transfusions ineffective. Despite a high incidence of maternal HLA antibodies in the pregnant population, there is only one previous report of clinically significant HLA antibodies.
Keywords: neonatal alloimmune thrombocytopenia (NAIT); HLA antibodies; apheresis; platelet transfusion
Abbreviations: NAIT, neonatal alloimmune thrombocytopenia; HPA, human platelet antigen
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This article has been cited by other articles:
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Roberts, I, Murray, N A
(2003). Neonatal thrombocytopenia: causes and management. Arch. Dis. Child. Fetal Neonatal Ed.
88: F359-F364
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