Case reports
Neonatal thrombocytosis resulting from the maternal use of
non-narcotic antischizophrenic drugs during pregnancy
Y Nako, A Tachibana, T Fujiu, T Tomomasa, A Morikawa
Department of
Paediatrics, Gunma University School of Medicine, Gunma, Japan
Correspondence to: Dr Nako, Department of Paediatrics, Gunma University School of Medicine, 3-39-15 Showa-machi, Maebashi, Gunma 371-8511, Japan yanako{at}showa.gunma-u.ac.jp
Accepted 4 January
2001
Neonatal thrombocytosis can result from maternal narcotic drug
abuse. The case of a male infant is reported who was born to a woman
with schizophrenia treated with non-narcotic psychotropic drugs during
pregnancy; he developed severe prolonged thrombocytosis. The platelet
count reached 1310 × 109/l on day 15. This
thrombocytosis persisted for three months. The patient was treated
with dipyridamole. A bone marrow aspirate showed normal myeloid and
erythroid precursors with an increased number of megakaryocytes. Plasma
concentrations of interleukin 6 and thrombopoietin were suppressed. No
obvious complications from the thrombocytosis occurred, and the
platelet count fell to within the upper limit of normal after 3 months
of age. This case indicates that thrombocytosis may occur in infants
born to mothers treated with non-narcotic psychopharmaceutical drugs
during pregnancy. The thrombocytosis in this case may have been induced by factors other than interleukin 6 or thrombopoietin.
Keywords: neonatal drug withdrawal syndrome; psychopharmaceuticals; thrombocytosis; thrombopoietin
© 2001 by Archives of Disease in Childhood
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