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Archives of Disease in Childhood - Fetal and Neonatal Edition 2001;84:F168-F171; doi:10.1136/fn.84.3.F168
Copyright © 2001 BMJ Publishing Group Ltd & Royal College of Paediatrics and Child Health.
Arch Dis Child Fetal Neonatal Ed 2001;84:F168-F171 ( May )

Type I collagenases in bronchoalveolar lavage fluid from preterm babies at risk of developing chronic lung disease

D G Sweeta, K J McMahonb, A E Curleya, C M O'Connorb, H L Hallidaya

a Department of Child Health, The Queen's University of Belfast and Regional Neonatal Unit, Royal Maternity Hospital, Belfast, Northern Ireland, b Department of Medicine and Therapeutics, University College Dublin, Republic of Ireland

Correspondence to: Dr Sweet, Perinatal Room, Royal Maternity Hospital, Grosvenor Road, Belfast BT12 6BB, Northern Ireland dsweet{at}dnet.co.uk

Accepted 23 November 2000

OBJECTIVE---To assess whether increased collagenolysis precedes severe chronic lung disease (CLD).
METHODS---Matrix metalloproteinase-1 (MMP-1) and MMP-8 (enzymes that degrade type I collagen, the main structural protein of lung extracellular matrix) were measured by enzyme linked immunosorbent assay in 100 bronchoalveolar lavage samples taken during the first 6 postnatal days from 45 ventilated preterm babies < 33 weeks gestation. The median value for each baby was calculated. CLD was defined as an oxygen requirement after the 36th week after conception.
RESULTS---MMP-8 levels in bronchoalveolar lavage fluid were higher (median 13 ng/ml) in 20 babies who developed CLD than in 25 without CLD (median 2 ng/ml). No MMP-1 was detected in any sample.
CONCLUSIONS---MMP-8 can be detected in bronchoalveolar lavage fluid from preterm babies, and higher levels are found in those who later develop CLD. MMP-8 may contribute to lung injury that occurs as a prelude to CLD.


Keywords: chronic lung disease; lungs; collagen; extracellular matrix; matrix metalloproteinase; preterm

© 2001 by Archives of Disease in Childhood
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