Brain specific proteins in posthaemorrhagic ventricular dilatation
A Whitelawa, L Rosengrenb, M Blennowc
a Division of Child
Health, University of Bristol, Bristol, UK, b Department of Neurology, Sahlgrenska Hospital,
Gothenburg, Sweden, c Department of Paediatrics, Huddinge Hospital,
Huddinge, Sweden
Correspondence to: Professor Whitelaw, Division of Child Health, University of Bristol Medical School, Southmead Hospital, Bristol BS10 5NB, UK email: andrew.whitelaw{at}bristol.ac.uk
Accepted 21 January
2000
Median neurofilament and glial fibrillary acidic protein
concentrations in the cerebrospinal fluid of 18 infants with
posthaemorrhagic ventricular dilatation were 20-200 times higher than
control values. S-100 protein in cerebrospinal fluid was four times
higher than control values. Glial fibrillary acidic protein
concentrations correlated with death or disability and with parenchymal
lesions but not with shunt dependence.
Keywords: cerebrospinal fluid; glial fibrillary acidic protein; posthaemorrhagic ventricular dilatation; brain; neurodevelopment
© 2001 by Archives of Disease in Childhood
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