|
|
||||||||||||||
|
|
|||||||||||||||
a Department of Child
Health, The Queen's University of Belfast and Regional Neonatal Unit,
Royal Maternity Hospital, Belfast, UK, b Department of
Haematology, The Queen's University of Belfast
Correspondence to: Dr D G Sweet, Perinatal Room, Royal Maternity Hospital, Grosvenor Road, Belfast BT12 6BB, Northern Ireland, UK dsweet{at}dnet.co.uk
Accepted 29 July 2000
AIMS
To determine effects of
maternal iron depletion and smoking on iron status of term babies using
serum transferrin receptors (STfR) and their ratio to ferritin (TfR-F
index) in cord blood.
METHODS
Iron, ferritin, STfR, and
haemoglobin (Hb) concentration were measured and TfR-F index calculated
in 67 cord /maternal blood pairs. Twenty six mothers were iron depleted
(ferritin <10 µg/l) and 28 were smokers.
RESULTS
Maternal iron depletion was
associated with decreased cord ferritin (113 v 171 µg/l) and Hb (156 v 168 g/l) but no change in STfR or TfR-F
index. Smoking was associated with increased cord Hb (168 v 157 g/l) and TfR-F index (4.1 v 3.4), and decreased ferritin (123 v 190 µg/l). Cord TfR-F index and Hb were
positively correlated (r = 0.48).
CONCLUSIONS
Maternal iron depletion
is associated with reduced fetal iron stores but no change in free iron
availability. Smoking is associated with increased fetal iron
requirements for erythropoiesis.
Related Articles
This article has been cited by other articles:
![]() |
A. Kumar, A. K. Rai, S. Basu, D. Dash, and J. S. Singh Cord Blood and Breast Milk Iron Status in Maternal Anemia Pediatrics, March 1, 2008; 121(3): e673 - e677. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. Maria Verner, J. Manderson, T. R J Lappin, D. R McCance, H. L Halliday, and D. G Sweet Influence of maternal diabetes mellitus on fetal iron status Arch. Dis. Child. Fetal Neonatal Ed., September 1, 2007; 92(5): F399 - F401. [Abstract] [Full Text] [PDF] |
||||
![]() |
G. Hay, H. Refsum, A. Whitelaw, E. L. Melbye, E. Haug, and B. Borch-Iohnsen Predictors of serum ferritin and serum soluble transferrin receptor in newborns and their associations with iron status during the first 2 y of life Am. J. Clinical Nutrition, July 1, 2007; 86(1): 64 - 73. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. S Golub, C. E Hogrefe, A. F Tarantal, S. L Germann, J. L Beard, M. K Georgieff, A. Calatroni, and B. Lozoff Diet-induced iron deficiency anemia and pregnancy outcome in rhesus monkeys Am. J. Clinical Nutrition, March 1, 2006; 83(3): 647 - 656. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. E. Cogswell, P. Weisberg, and C. Spong Cigarette Smoking, Alcohol Use and Adverse Pregnancy Outcomes: Implications for Micronutrient Supplementation J. Nutr., May 1, 2003; 133(5): 1722S - 1731. [Abstract] [Full Text] [PDF] |
||||
![]() |
P REYNOLDS, H L HALLIDAY, and T R J LAPPIN Newborns have unique confounding factors regarding the TfR-F ratio Reply Arch. Dis. Child. Fetal Neonatal Ed., September 1, 2001; 85(2): F145c - 145. [Full Text] |
||||
Read all eLetters
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS | REGISTER |
| ARCH DIS CHILD | FETAL NEONATAL ED | ED PRACTICE |