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Arch Dis Child Fetal Neonatal Ed 2001;84:F40-F43 ( January )

Study of maternal influences on fetal iron status at term using cord blood transferrin receptors

D G Sweeta, G Savageb, T R J Tubmana, T R J Lappinb, H L Hallidaya

a Department of Child Health, The Queen's University of Belfast and Regional Neonatal Unit, Royal Maternity Hospital, Belfast, UK, b Department of Haematology, The Queen's University of Belfast

Correspondence to: Dr D G Sweet, Perinatal Room, Royal Maternity Hospital, Grosvenor Road, Belfast BT12 6BB, Northern Ireland, UK dsweet{at}dnet.co.uk

Accepted 29 July 2000

AIMS---To determine effects of maternal iron depletion and smoking on iron status of term babies using serum transferrin receptors (STfR) and their ratio to ferritin (TfR-F index) in cord blood.
METHODS---Iron, ferritin, STfR, and haemoglobin (Hb) concentration were measured and TfR-F index calculated in 67 cord /maternal blood pairs. Twenty six mothers were iron depleted (ferritin <10 µg/l) and 28 were smokers.
RESULTS---Maternal iron depletion was associated with decreased cord ferritin (113 v 171 µg/l) and Hb (156 v 168 g/l) but no change in STfR or TfR-F index. Smoking was associated with increased cord Hb (168 v 157 g/l) and TfR-F index (4.1 v 3.4), and decreased ferritin (123 v 190 µg/l). Cord TfR-F index and Hb were positively correlated (r = 0.48).
CONCLUSIONS---Maternal iron depletion is associated with reduced fetal iron stores but no change in free iron availability. Smoking is associated with increased fetal iron requirements for erythropoiesis.


Keywords: iron status; pregnancy; smoking; transferrin receptors

© 2001 by Archives of Disease in Childhood

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eLetters:

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Newborns have unique confounding factors regarding the TfR-F ratio
Peter Reynolds
Fetal Neonatal Ed. Online, 12 Jan 2001 [Full text]
Newborns have unique confounding factors regarding the TfR-F ratio - Authors' response
Henry L Halliday
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Translational regulation of TfR and ferritin
Peter Reynolds
Fetal Neonatal Ed. Online, 14 Feb 2001 [Full text]
Translational regulation of TfR and ferritin - Authors' response
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