Randomised trial of iodine intake and thyroid status in preterm infants
Jenny Rogahna, Steven Ryanb, John Wellsd, Bill Fraserc, Christine Squirec, Nick Wildg, Adrian Hughesf, Laweh Amegaviee
a Neonatal Unit,
Liverpool Women's Hospital, Liverpool, UK, b Royal Liverpool Children's NHS Trust, Alder Hey
Hospital, Liverpool, c Department of
Clinical Chemistry, Royal Liverpool University Hospital, Liverpool, d Cow and
Gate Nutricia Limited, Trowbridge, Wiltshire, UK, e Paediatric Department, Whiston Hospital,
Merseyside, UK, f Paediatric
Department, Arrowe Park Hospital, Merseyside, g Paediatric Department, Warrington Hospital,
Merseyside
Correspondence to: Dr Ryan, RLC NHS Trust, Alder Hey Hospital, Liverpool L12 2AP, UK email: Steve.Ryan{at}RLCH-TR.NWEST.NHS.UK
Accepted 28 April 2000
BACKGROUND
Low levels
of circulating thyroid hormones have been associated with poorer
general and neurodevelopmental outcome in preterm babies and it has
been speculated that the association is causal. Low levels of
circulating thyroid hormone have been reported after inadequate intake
of iodine in preterm infants being fed milk formula.
AIMTo investigate
whether increased iodine intake from supplemented preterm formula would
improve thyroid hormone levels in preterm babies (this study) and hence
improve neurodevelopmental status (planned subsequent study).
METHODA total of 121 preterm infants were entered into a randomised controlled trial of
standard (68 µg/l) versus increased (272 µg/l) iodine in preterm formula.
RESULTSThe two groups
were comparable at recruitment. No evidence of an effect of the
intervention on thyroid hormone levels was seen up to 41 weeks after conception.
CONCLUSIONCalls for
increased iodine content of preterm infant formulas are not justified
by this study.
|
Key message
|
Keywords: premature; randomised controlled trial; iodine; thyroid function; milk formula
© 2000 by Archives of Disease in Childhood
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
-
Ristic-Medic, D., Piskackova, Z., Hooper, L., Ruprich, J., Casgrain, A., Ashton, K., Pavlovic, M., Glibetic, M.
(2009). Methods of assessment of iodine status in humans: a systematic review. Am. J. Clin. Nutr.
89: 2052S-2069S
[Abstract] [Full Text] -
Ibrahim, M, de Escobar, G M., Visser, T J, Duran, S, van Toor, H, Strachan, J, Williams, F L R, Hume, R
(2003). Iodine deficiency associated with parenteral nutrition in extreme preterm infants. Arch. Dis. Child. Fetal Neonatal Ed.
88: F56-57
[Abstract] [Full Text]
- Full Text
- Full Text (PDF)
- Submit a response
- Alert me when this article is cited
- Alert me when eLetters are posted
- Alert me if a correction is posted
- Citation Map
Services
- Email this link to a friend
- Similar articles in ADC Online
- Similar articles in PubMed
- Add article to my folders
- Download to citation manager
- Request Permissions
Citing Articles
Google Scholar
PubMed
Topic Collections
Bookmark with
Register for free content
The full back archive is now available for all BMJ Journals. Institutional subscribers may access the entire archive as part of their subscription. Personal subscribers will also have access to all content when logged in. Non-subscribers who register have free access to all articles published before 2006 right back to volume 1 issue 1. Register here to access the free archive of all BMJ Journals.
Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.
