Cardiovascular effects of an intravenous bolus of morphine in the ventilated preterm infant
N Ruttera, N Evansb
a Division of Child
Health, School of Human Development, University of Nottingham, Queen's
Medical Centre, Nottingham NG7 2UH, UK, b Department of Neonatal Medicine, University of
Sydney, Royal Prince Alfred Hospital, NSW 2050, Australia
Correspondence to: Professor Rutter email: Nick.Rutter{at}nottingham.ac.uk
Accepted 27 March 2000
AIM
To examine the
cardiovascular effects of an intravenous bolus of morphine, 100 µg/kg, in 17 ventilated preterm infants.
METHODSHeart rate and
blood pressure were monitored. Right ventricular output, superior vena
caval flow, and the width of the ductus arteriosus were measured by
Doppler echocardiography 10 and 60 minutes after the morphine
injection, and the values compared with baseline values by the paired
t test.
RESULTSThere was a
small but significant fall in heart rate (2.1% at 10 minutes, 4.3% at
60 minutes) consistent with a sedative effect. There was no effect on
systolic, diastolic, or mean blood pressure. There was no significant
effect on systemic blood flow as measured by either right ventricular
output or superior vena caval flow. Ductal width was significantly
reduced by a mean of 16% at 60 minutes, suggesting that normal duct
closure was not inhibited.
CONCLUSIONNo
cardiovascular effects of an intravenous bolus of morphine could be detected.
Keywords: preterm; opiate; morphine; analgesia; sedation; cardiovascular
© 2000 by Archives of Disease in Childhood
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